Jose A Lemos

Jose A Lemos Ph.D.

ASSOCIATE PROFESSOR

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8843
Business Email: jlemos@dental.ufl.edu

About Jose A Lemos

José A. Lemos obtained his PhD (Microbiology and Immunology) from the Federal University of Rio de Janeiro (Brazil) in 2000. He did postdoctoral research at the University of Rochester and later at the University of Florida. In 2003, he was promoted to Research Assistant Professor in the Department of Oral Biology at the University of Florida. In 2007, he joined the faculty of the University of Rochester in the Center of Oral Biology and Department of Microbiology and Immunology. In 2015, he returned to the University of Florida College of Dentistry as part of the Preeminance hire initiative where he is currently an Associate Professor in the Department of Oral Biology. His laboratory investigates the stress survival mechanisms of Firmicutes with a particular focus on S. mutans and Enterococcus faecalis.

Honors & Awards

(BACP Study section) – Permanent
2017 · NIH/NIAID
Co-organizer
2016 · 8th ASM Conference on Streptococcal Genetics, Washington D.C.
(BACP Study section) – Temporary
2016 · NIH/NIAID
(PCMB Study section) – Temporary
2016 · NIH/NIAID
(ODCS study section) – Temporary
2016 · NIH/NIDCR
(DSR1 study section) – Temporary
2015 · NIH/NIDCR
Co-chair
2011 · Conference on Oral Biology: Post-genomics for the oral microbiome. Rochester, NY
Chair
2010 · Rochester Section of the American Association for Dental Research
Travel Fellowship Award
1999 · ASM Mini-course Molecular Aspects of Microbial Pathogenesis, Santiago de Chile (Chile)
Travel Fellowship Award
1998 · ASM Conference on Streptococcal Genetics, Vichy (France)
Postgraduate exchange fellowship
1997 · CAPES- Coordination for the Improvement of Higher Education Personnel

Research Profile

My Laboratory investigates the molecular factors that mediate virulence in the opportunistic Gram-positive pathogens Streptococcus mutans and Enterococcus faecalis. S. mutans is a major pathogen in dental caries and a leading causative agent of infective endocarditis. In S. mutans, our current efforts focus on the characterization of the oxidative stress regulator Spx, and its role in controlling stress responses and biofilm formation. The second S. mutans project focuses on the characterization of a collagen binding protein responsible for intracellular invasion of heart and oral tissues, a trait that is linked to increased virulence and, potentially, recurrent infection and chronic inflammation. The characterization of stress responses is also the theme of our research with E. faecalis, a leading cause of hospital-acquired infections. In this project, we are investigating the interplay between regulatory nucleotides (i.e., ppGpp, c-di-AMP) with other prominent stress regulators and how these interactions influence the ability of E. faecalis to survive antibiotic stress and other adverse conditions.

Areas of Interest
  • Streptococcus
  • Dental caries
  • Stress responses
  • Enterococcus
  • Biofilm
  • Oxidative stress
  • Antibiotic resistance

Grants

July 2019ACTIVE
Intracellular Invasion by Streptococcus mutans: Significance in Disease
NATL INST OF HLTH NIDCR ·
May 2018ACTIVE
Significance of metal homeostasis to bacterial pathogenesis in chronic wounds
NATL INST OF HLTH NIAID · Principal Investigator
January 2018ACTIVE
Regulatory Nucleotides of Enterococcus faecalis
NATL INST OF HLTH NIAID · Principal Investigator
July 2016ACTIVE
Role of the Spx Regulator in Streptococcus mutans
NATL INST OF HLTH NIDCR · Principal Investigator
July 2016 – June 2018
Significance of manganese homeostasis to enterococcus faecalis systemic infections
AMER HEART ASSOCIATION · Mentor
August 2015 – March 2019
Intracellular Invasion by Streptococcus mutans: Significance in Disease
NATL INST OF HLTH NIDCR · Principal Investigator

Patents

Issued November 2015
Methods for Predicting and Preventing Cardiovascular Disease
9,176,135

Education

2000
Ph.D. in Microbiology and Immunology
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
1995
M.S. in Microbiology and Immunology
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
1990
B.S. in Biology
Santa Ursula University, Rio de Janeiro, Brazil

Contact Details

Phones:
Business:
(352) 273-8843
Emails:
Addresses:
Mailing:
PO Box 100424
GAINESVILLE, FL 32610
Physical:
DEPARTMENT OF ORAL BIOLOGY
1395 CENTER DRIVE
DEPARTMENT OF ORAL BIOLOGY
GAINESVILLE, FL 326100001