William A Dunn

William A Dunn,

Professor

Department: MD-ANATOMY
Business Phone: (352) 273-9007
Business Email: dunn@ufl.edu

Publications

2017
Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0171940. [PMID] 28222108.
2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12(1):1-222 [DOI] 10.1080/15548627.2015.1100356. [PMID] 26799652.
2016
Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner.
Cell death and differentiation. 23(2):279-90 [DOI] 10.1038/cdd.2015.96. [PMID] 26184910.
2014
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors.
Autophagy. 10(11):2021-35 [DOI] 10.4161/auto.32229. [PMID] 25483883.
2014
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
Autophagy. 10(11):1989-2005 [DOI] 10.4161/auto.36184. [PMID] 25484094.
2014
Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice.
Neurobiology of disease. 70:224-36 [DOI] 10.1016/j.nbd.2014.06.023. [PMID] 25014022.
2013
Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.
Experimental gerontology. 48(10):1107-19 [DOI] 10.1016/j.exger.2013.01.006. [PMID] 23337777.
2013
Deletion of lipoprotein PG0717 in Porphyromonas gingivalis W83 reduces gingipain activity and alters trafficking in and response by host cells.
PloS one. 8(9) [DOI] 10.1371/journal.pone.0074230. [PMID] 24069284.
2013
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.
Autophagy. 9(3):328-44 [DOI] 10.4161/auto.22971. [PMID] 23298947.
2012
Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.
Sub-cellular biochemistry. 57:161-86 [DOI] 10.1007/978-94-007-2561-4_8. [PMID] 22094422.
2012
Autophagy in the retina: a potential role in age-related macular degeneration.
Advances in experimental medicine and biology. 723:83-90 [DOI] 10.1007/978-1-4614-0631-0_12. [PMID] 22183319.
2012
Hydrogen Sulfide Reduces Gfp-Tagged Autophagosomes in Vitro
The FASEB's Journal. 26
2012
Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study.
PloS one. 7(12) [DOI] 10.1371/journal.pone.0052606. [PMID] 23300720.
2011
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice.
Gastroenterology. 141(6):2188-2199.e6 [DOI] 10.1053/j.gastro.2011.08.005. [PMID] 21854730.
2010
Overexpression of Atg4B and Beclin-1 Enhances Liver Mitochondrial-Autophagy and Prevents the Age-Associated Ischemia/Reperfusion Injury To Mouse Liver
Higher Education Policy. 52
2010
Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(34):11388-97 [DOI] 10.1523/JNEUROSCI.1356-10.2010. [PMID] 20739560.
2009
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae.
Aging cell. 8(4):353-69 [DOI] 10.1111/j.1474-9726.2009.00469.x. [PMID] 19302372.
2009
Autophagy is required for extension of yeast chronological life span by rapamycin.
Autophagy. 5(6):847-9 [PMID] 19458476.
View on: PubMed
2009
Identification of Compounds That Enhance and Suppress Autophagy
Autophagy. 5:910-911
2009
Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease.
Neurobiology of disease. 34(1):146-54 [PMID] 19320048.
View on: PubMed
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology. 24(2):141-5 [DOI] 10.1111/j.1399-302X.2008.00487.x. [PMID] 19239641.
2009
Using LC3 to monitor autophagy flux in the retinal pigment epithelium.
Autophagy. 5(8):1190-3 [PMID] 19855195.
View on: PubMed
2008
Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury.
Biochemical and biophysical research communications. 373(4):478-81 [DOI] 10.1016/j.bbrc.2008.05.031. [PMID] 18486600.
2008
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy. 4(2):151-75 [PMID] 18188003.
View on: PubMed
2008
Impaired Autophagy Contributes To Resistance of Cirrhotic Liver-Derived Hepatocytes To Transforming Growth Factor Beta (Tgf Beta)-Induced Apoptosis
Higher Education Policy. 48
2008
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes.
Hepatology (Baltimore, Md.). 47(5):1725-36 [DOI] 10.1002/hep.22187. [PMID] 18311843.
2008
Porphyromonas Gingivalis and the Autophagic Pathway: An Innate Immune Interaction?
The Journal of pharmacy and pharmacology. 13(12):178-187 [DOI] 10.2741/2668. [PMID] 2668.
2008
Porphyromonas gingivalis and the autophagic pathway: an innate immune interaction?
Frontiers in bioscience : a journal and virtual library. 13:178-87 [PMID] 17981536.
View on: PubMed
2008
Porphyromonas gingivalis htrA is involved in cellular invasion and in vivo survival.
Microbiology (Reading, England). 154(Pt 4):1161-1169 [DOI] 10.1099/mic.0.2007/015131-0. [PMID] 18375808.
2008
The membrane dynamics of pexophagy are influenced by Sar1p in Pichia pastoris.
Molecular biology of the cell. 19(11):4888-99 [DOI] 10.1091/mbc.E07-09-0868. [PMID] 18768759.
2007
Autophagy in the heart and liver during normal aging and calorie restriction.
Rejuvenation research. 10(3):281-92 [PMID] 17665967.
View on: PubMed
2007
Developmental abnormalities in the nerves of peripheral myelin protein 22-deficient mice.
Journal of neuroscience research. 85(2):238-49 [PMID] 17131416.
View on: PubMed
2007
How shall I eat thee?
Autophagy. 3(5):413-6 [PMID] 17568180.
View on: PubMed
2007
Identification of pexophagy genes by restriction enzyme-mediated integration.
Methods in molecular biology (Clifton, N.J.). 389:203-18 [PMID] 17951645.
View on: PubMed
2007
The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones.
Neurobiology of disease. 25(2):252-65 [PMID] 17174099.
View on: PubMed
2007
The Porphyromonas gingivalis clpB gene is involved in cellular invasion in vitro and virulence in vivo.
FEMS immunology and medical microbiology. 51(2):388-98 [PMID] 17854400.
View on: PubMed
2006
Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression.
Neurobiology of disease. 22(1):153-64 [PMID] 16326107.
View on: PubMed
2006
Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1.
Apoptosis : an international journal on programmed cell death. 11(9):1573-82 [PMID] 16703260.
View on: PubMed
2006
Autophagy: a highway for Porphyromonas gingivalis in endothelial cells.
Autophagy. 2(3):165-70 [PMID] 16874051.
View on: PubMed
2006
Early and late molecular events of glucose-induced pexophagy in Pichia pastoris require Vac8.
Autophagy. 2(4):280-8 [PMID] 16921262.
View on: PubMed
2006
Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(4):1179-89 [PMID] 16436605.
View on: PubMed
2006
PpAtg9 trafficking during micropexophagy in Pichia pastoris.
Autophagy. 2(1):52-4 [PMID] 16874077.
View on: PubMed
2005
Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.
Arteriosclerosis, thrombosis, and vascular biology. 25(3):e17-8 [PMID] 15662025.
View on: PubMed
2005
Pexophagy: the selective autophagy of peroxisomes.
Autophagy. 1(2):75-83 [PMID] 16874024.
View on: PubMed
2005
PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris.
Molecular biology of the cell. 16(10):4941-53 [PMID] 16079180.
View on: PubMed
2003
A unified nomenclature for yeast autophagy-related genes.
Developmental cell. 5(4):539-45 [PMID] 14536056.
View on: PubMed
2003
Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy.
The Journal of biological chemistry. 278(48):48445-52 [PMID] 14504273.
View on: PubMed
2003
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy.
Molecular biology of the cell. 14(2):477-90 [PMID] 12589048.
View on: PubMed
2003
Emerging role for autophagy in the removal of aggresomes in Schwann cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(33):10672-80 [PMID] 14627652.
View on: PubMed
2002
Bacterial interactions with the autophagic pathway.
Cellular microbiology. 4(1):1-10 [PMID] 11856168.
View on: PubMed
2001
Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways.
The Journal of biological chemistry. 276(32):30442-51 [PMID] 11382760.
View on: PubMed
2001
Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris.
Molecular biology of the cell. 12(12):3821-38 [PMID] 11739783.
View on: PubMed
2001
Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole.
The Journal of cell biology. 153(2):381-96 [PMID] 11309418.
View on: PubMed
2001
GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris.
The Journal of biological chemistry. 276(45):42422-35 [PMID] 11533052.
View on: PubMed
2001
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.
The Journal of biological chemistry. 276(32):30407-13 [PMID] 11399750.
View on: PubMed
2001
Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells.
Infection and immunity. 69(9):5698-708 [PMID] 11500446.
View on: PubMed
2001
Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport.
Journal of cellular physiology. 187(1):48-58 [PMID] 11241348.
View on: PubMed
2000
Dissection of autophagosome biogenesis into distinct nucleation and expansion steps.
The Journal of cell biology. 151(5):1025-34 [PMID] 11086004.
View on: PubMed
1999
Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein.
Molecular biology of the cell. 10(5):1353-66 [PMID] 10233149.
View on: PubMed
1999
Invasion of human coronary artery cells by periodontal pathogens.
Infection and immunity. 67(11):5792-8 [PMID] 10531230.
View on: PubMed
1999
Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis.
Journal of cellular physiology. 178(1):17-27 [PMID] 9886486.
View on: PubMed
1997
Glucose-induced microautophagy in Pichia pastoris requires the alpha-subunit of phosphofructokinase.
Journal of cell science. 110 ( Pt 16):1935-45 [PMID] 9296392.
View on: PubMed
1995
Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris.
Journal of cell science. 108 ( Pt 1):25-35 [PMID] 7738102.
View on: PubMed
1994
Autophagy and related mechanisms of lysosome-mediated protein degradation.
Trends in cell biology. 4(4):139-43 [PMID] 14731737.
View on: PubMed
1994
Growth factor-induced neurite growth in primary neuronal cultures of dogs with neuronal ceroid lipofuscinosis.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 12(3):185-96 [PMID] 7942092.
View on: PubMed
1993
Selective autophagy of peroxisomes in methylotrophic yeasts.
European journal of cell biology. 60(2):283-90 [PMID] 8330626.
View on: PubMed
1992
A novel mechanism for isoprenaline-stimulated proliferation of rat parotid acinar cells involving the epidermal growth factor receptor and cell surface galactosyltransferase.
The Biochemical journal. 284 ( Pt 3):767-76 [PMID] 1622394.
View on: PubMed
1992
Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles.
Journal of cellular physiology. 152(3):458-66 [PMID] 1506410.
View on: PubMed
1992
Effects of streptozotocin-induced diabetes on rough endoplasmic reticulum and lysosomes of rat liver.
The American journal of physiology. 263(5 Pt 1):E856-62 [PMID] 1443117.
View on: PubMed
1992
Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum.
The Journal of cell biology. 117(5):959-73 [PMID] 1374417.
View on: PubMed
1992
Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles.
The Journal of cell biology. 118(2):301-8 [PMID] 1321157.
View on: PubMed
1991
Identification of epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in surgically induced endometriosis in rats.
Obstetrics and gynecology. 78(5 Pt 1):850-7 [PMID] 1923211.
View on: PubMed
1991
Regulation of protein secretion by crinophagy in perfused rat liver.
European journal of cell biology. 56(2):201-9 [PMID] 1724960.
View on: PubMed
1990
Studies on the mechanisms of autophagy: formation of the autophagic vacuole.
The Journal of cell biology. 110(6):1923-33 [PMID] 2351689.
View on: PubMed
1990
Studies on the mechanisms of autophagy: maturation of the autophagic vacuole.
The Journal of cell biology. 110(6):1935-45 [PMID] 2161853.
View on: PubMed

Grants

Mar 2020 – Jun 2021
Integrated transcriptomics and metabolomics approach to define pathogenicity of P.gingivalis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2019 ACTIVE
Investigating the viable but not culturable (VBNC) state in P. gingivalis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2019 – Jun 2020
The American Society for Cell Biology Early Career Meeting Grant Application Requirements
Role: Project Manager
Funding: AMERICAN SOCIETY FOR CELL BIOLOGY
Apr 2015 – Mar 2021
P. gingivalis mediated disruption of autophagy in endothelial dysfunction
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Jul 2013 – Dec 2016
Internalization of S. mutans in vascular endothelial cells
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Dec 2012 – Dec 2018
Research fund- Anatomy & cell Biology
Role: Principal Investigator
Funding: UF FOUNDATION

Patents

Issued October 2013
Novel Compounds that Suppress the Autophagic Response
#8,545,841
Published February 2012
Methods and Compositions for the Treatment of Cancers and Pathogenic Infections
#US-2012-0141491-A1
Published December 2009
Materials and Methods for Enchanced Degradation of Mutant Proteins Associated with Human Disease
#US 2010-0087474 A1

Teaching Profile

Courses Taught
2013-2014,2016-2019,2018-2021
GMS6635 Organization of Cells and Tissues
2011-2013,2018-2021
GMS6690 Molecular Cell Biology Journal Club
2019-2021
GMS5057 Medical Cell Biology
2013-2021
GMS5630 Medical Histology
2013-2014,2016-2021
GMS6001 Fundamentals of Biomedical Sciences I
2013-2014,2019-2021
BMS6031 Foundations of Med
2020-2021
GMS6691 Special Topics in Cell Biology and Anatomy
2020-2021
BMS6632 Endo and Reproduction
2014,2016-2020,2020-2021
GMS6421 Cell Biology
2017,2019-2021
BMS4136C Human Histology
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2014,2016-2018
GMS6062 Protein Trafficking
2018
BMS6300 Fund Micro and Immuno
2016-2017
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2016
GMS6644 Apoptosis
2015
BMS6638C Kidney & Urinary Tract
2014,2021
GMS6692 Research Conference in Anatomy and Cell Biology
2021
GMS6063 Cell Biology of Aging

Contact Details

Phones:
Business:
(352) 273-9007
Emails:
Business:
dunn@ufl.edu