Ana Duran-Pinedo

Ana Duran-Pinedo

Research Assistant Professor

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Research Profile

My research main interest is to understand the role of Tannerella forsythia on the development of periodontal disease with particular focus on the study of new putative virulence factors. T. forsythia is a major periodontal pathogen strongly associated with periodontitis and a member of the Red complex (Tannerella forsythia, Porphyromonas gingivalis and Treponema denticola). It was first isolated at Forsyth Institute by Anne Tanner and Sig Socransky, and named in recognition to its discoverers and the Institute. As standpoint, I have studied the gene expression profiles of oral communities on progressing and stablished periodontitis using Metatranscriptomic analysis. I have focused my research on understanding what is happening to T.forsythia, in the real context of the complex oral microbial communities and the host. We have found that during disease progression T.Forsythia is expressing at high level a protein causing collagen destruction in the tooth supporting structures. Collagen is the main component on the periodontium and its degradation lead to the loss of tooth, decreasing the quality of life of the patient. For the last 14 years I have been working on the biology of the anaerobes. As a postdoctoral fellow at University of Illinois at Champaign-Urbana, I carried out research on in vivo recombination of Bacteroides conjugative transposon CtnDOT, a genetic element involved in the spread of erythromycin resistance. Later on, I moved to The Forsyth Institute, where I started my research on the study of the genes controlled by Two Component Systems most in P.gingivalis. As mentioned above, currently, the main focus of my research is understanding the contribution of Tannerella forsythia to the progression and development of periodontitis

Areas of Interest
  • Education
  • Microbiology
  • Microbiome


Metatranscriptomic analyses of the oral microbiome.
Periodontology 2000. 85(1):28-45 [DOI] 10.1111/prd.12350. [PMID] 33226688.
Virulence of the Pathogen Porphyromonas gingivalis Is Controlled by the CRISPR-Cas Protein Cas3.
mSystems. 5(5) [DOI] 10.1128/mSystems.00852-20. [PMID] 32994292.
The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome.
NPJ biofilms and microbiomes. 4 [DOI] 10.1038/s41522-018-0068-z. [PMID] 30345066.
The contribution of Tannerella forsythia dipeptidyl aminopeptidase IV in the breakdown of collagen.
Molecular oral microbiology. 33(6):407-419 [DOI] 10.1111/omi.12244. [PMID] 30171738.
Potassium is a key signal in host-microbiome dysbiosis in periodontitis.
PLoS pathogens. 13(6) [DOI] 10.1371/journal.ppat.1006457. [PMID] 28632755.
Small RNA Transcriptome of the Oral Microbiome during Periodontitis Progression.
Applied and environmental microbiology. 81(19):6688-99 [DOI] 10.1128/AEM.01782-15. [PMID] 26187962.
Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis.
Genome medicine. 7(1) [DOI] 10.1186/s13073-015-0153-3. [PMID] 25918553.
Beyond microbial community composition: functional activities of the oral microbiome in health and disease.
Microbes and infection. 17(7):505-16 [DOI] 10.1016/j.micinf.2015.03.014. [PMID] 25862077.
Erratum to: Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis.
Genome medicine. 7(1) [DOI] 10.1186/s13073-015-0231-6. [PMID] 26507874.
Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis.
The ISME journal. 8(8):1659-72 [DOI] 10.1038/ismej.2014.23. [PMID] 24599074.
The periodontal pathogen Porphyromonas gingivalis induces expression of transposases and cell death of Streptococcus mitis in a biofilm model.
Infection and immunity. 82(8):3374-82 [DOI] 10.1128/IAI.01976-14. [PMID] 24866802.
A two-component system regulates hemin acquisition in Porphyromonas gingivalis.
PloS one. 8(9) [DOI] 10.1371/journal.pone.0073351. [PMID] 24039921.
Effect of periodontal pathogens on the metatranscriptome of a healthy multispecies biofilm model.
Journal of bacteriology. 194(8):2082-95 [DOI] 10.1128/JB.06328-11. [PMID] 22328675.
Correlation network analysis applied to complex biofilm communities.
PloS one. 6(12) [DOI] 10.1371/journal.pone.0028438. [PMID] 22163302.
The RprY response regulator of Porphyromonas gingivalis.
Molecular microbiology. 64(4):1061-74 [PMID] 17501928.
View on: PubMed


Nov 2016 – Jul 2018
Highly up regulated proteins in Tannerella Forsythia during periodontal disease
Role: Principal Investigator


PhD Biological Sciences
2001 · University of Barcelona
Master Microbiology
1998 · Autonomic University of Barcelona
Bs Bacteriology
1994 · Xaveriana University- Colombia

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