Shouguang Jin

Shouguang Jin,

PROFESSOR

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5973
Business Email: sjin@ufl.edu

Publications

2021
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.
Journal of medicinal chemistry. 64(11):7275-7295 [DOI] 10.1021/acs.jmedchem.1c00168. [PMID] 33881312.
2021
An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications.
Organic & biomolecular chemistry. 19(30):6603-6608 [DOI] 10.1039/d1ob01107c. [PMID] 34286808.
2021
Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications.
Organic & biomolecular chemistry. 19(7):1483-1487 [DOI] 10.1039/d0ob02428g. [PMID] 33521803.
2020
High-efficiency protein delivery into transfection-recalcitrant cell types.
Biotechnology and bioengineering. 117(3):816-831 [DOI] 10.1002/bit.27245. [PMID] 31814110.
2020
Molecular genetic analysis of an XDR Pseudomonas aeruginosa ST664 clone carrying multiple conjugal plasmids
Journal of Antimicrobial Chemotherapy. 75(6):1443-1452 [DOI] 10.1093/jac/dkaa063. [PMID] 32129854.
2020
PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids
Nucleic Acids Research. 48(11):5967-5985 [DOI] 10.1093/nar/gkaa377. [PMID] 32406921.
2020
TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa
Mbio. 11(1) [DOI] 10.1128/mBio.02079-19. [PMID] 31911486.
2019
Combination of Azithromycin and Gentamicin for Efficient Treatment of Pseudomonas aeruginosa Infections.
The Journal of infectious diseases. 220(10):1667-1678 [DOI] 10.1093/infdis/jiz341. [PMID] 31419286.
2019
Identification of a small RNA that directly controls the translation of the quorum sensing signal synthase gene rhlI in Pseudomonas aeruginosa.
Environmental microbiology. 21(8):2933-2947 [DOI] 10.1111/1462-2920.14686. [PMID] 31106966.
2019
Identification of novel genes that promote persister formation by repressing transcription and cell division in Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy. 74(9):2575-2587 [DOI] 10.1093/jac/dkz214. [PMID] 31139822.
2019
NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa
Frontiers in Microbiology. 10 [DOI] 10.3389/fmicb.2019.00085. [PMID] 30761117.
2019
Oligoribonuclease Contributes to Tolerance to Aminoglycoside and β-Lactam Antibiotics by Regulating KatA in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy. 63(6) [DOI] 10.1128/AAC.00212-19. [PMID] 30936107.
2019
Pseudomonas aeruginosa ExsA Regulates a Metalloprotease, ImpA, That Inhibits Phagocytosis of Macrophages.
Infection and immunity. 87(12) [DOI] 10.1128/IAI.00695-19. [PMID] 31527124.
2019
Pseudomonas aeruginosa Polynucleotide Phosphorylase Contributes to Ciprofloxacin Resistance by Regulating PrtR.
Frontiers in microbiology. 10 [DOI] 10.3389/fmicb.2019.01762. [PMID] 31417536.
2019
The Pseudomonas aeruginosa HSP70-like protein DnaK induces IL-1β expression via TLR4-dependent activation of the NF-κB and JNK signaling pathways.
Comparative immunology, microbiology and infectious diseases. 67 [DOI] 10.1016/j.cimid.2019.101373. [PMID] 31704499.
2018
A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter Beta-Lactamase Resistance in Pseudomonas Aeruginosa
Slas Discovery. 23(1):55-64 [DOI] 10.1177/2472555217728489. [PMID] 28850797.
2018
An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.
Journal of medicinal chemistry. 61(9):3962-3983 [DOI] 10.1021/acs.jmedchem.7b01903. [PMID] 29638121.
2018
Bacterial type III secretion system as a protein delivery tool for a broad range of biomedical applications.
Biotechnology advances. 36(2):482-493 [DOI] 10.1016/j.biotechadv.2018.01.016. [PMID] 29409784.
2018
Construction of a Protective Vaccine Against Lipopolysaccharide-Heterologous Pseudomonas Aeruginosa Strains Based on Expression Profiling of Outer Membrane Proteins During Infection
Frontiers in Immunology. 9 [DOI] 10.3389/fimmu.2018.01737. [PMID] 30093906.
2018
Enhanced Differentiation of Human Pluripotent Stem Cells Into Cardiomyocytes By Bacteria-Mediated Transcription Factors Delivery
PLoS One. 13(3) [DOI] 10.1371/journal.pone.0194895. [PMID] 29579079.
2018
Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis.
European journal of medicinal chemistry. 155:705-713 [DOI] 10.1016/j.ejmech.2018.06.045. [PMID] 29936357.
2018
HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa.
Toxins. 10(11) [DOI] 10.3390/toxins10110424. [PMID] 30355991.
2018
Mechanisms of RsaL mediated tolerance to ciprofloxacin and carbenicillin in Pseudomonas aeruginosa.
Current Genetics. 65(1):213-222 [DOI] 10.1007/s00294-018-0863-3. [PMID] 29951698.
2018
PA5470 Counteracts Antimicrobial Effect of Azithromycin by Releasing Stalled Ribosome in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy. 62(2) [DOI] 10.1128/AAC.01867-17. [PMID] 29203495.
2018
Pseudomonas aeruginosa.
Frontiers in microbiology. 9 [DOI] 10.3389/fmicb.2018.00548. [PMID] 29632523.
2018
Regulatory Protein Srpa Controls Phage Infection and Core Cellular Processes in Pseudomonas Aeruginosa
Nature Communications. 9(1) [DOI] 10.1038/s41467-018-04232-6. [PMID] 29748556.
2018
Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival.
Angewandte Chemie (International ed. in English). 57(47):15523-15528 [DOI] 10.1002/anie.201809785. [PMID] 30230671.
2017
A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-01045-3. [PMID] 28515440.
2017
Fis Regulates Type III Secretion System By Influencing the Transcription of Exsa in Pseudomonas Aeruginosa Strain Pa14
Frontiers in Microbiology. 8 [DOI] 10.3389/fmicb.2017.00669. [PMID] 28469612.
2017
In Vivo Host Environment Alters Pseudomonas Aeruginosa Susceptibility to Aminoglycoside Antibiotics
Frontiers in Cellular and Infection Microbiology. 7 [DOI] 10.3380/fcimb.2017.00083.
2017
Suhb Regulates the Motile-Sessile Switch in Pseudomonas Aeruginosa Through the Gac/Rsm Pathway and C-Di-Gmp Signaling
Frontiers in microbiology. 8 [DOI] 10.3389/fmicb.2017.01045. [PMID] 28642753.
2016
Epidemiological Characterization of Acinetobacter Baumannii Bloodstream Isolates From a Chinese Burn Institute: a Three-Year Study
Burns. 42(7):1542-1547 [DOI] 10.1016/j.burns.2016.02.021.
2016
Identification of D-amino acid dehydrogenase as an upstream regulator of the autoinduction of a putative acyltransferase in Corynebacterium glutamicum.
Journal of microbiology (Seoul, Korea). 54(6):432-9 [DOI] 10.1007/s12275-016-6046-3. [PMID] 27225460.
2016
Oligoribonuclease Is Required for the Type III Secretion System and Pathogenesis of Pseudomonas Aeruginosa
Microbiological Research. 188:90-96 [DOI] 10.1016/j.micres.2016.05.002.
2016
PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa.
Frontiers in microbiology. 7 [DOI] 10.3389/fmicb.2016.00317. [PMID] 27014238.
2016
Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa.
Frontiers in microbiology. 7 [DOI] 10.3389/fmicb.2016.00247. [PMID] 26973625.
2016
Pseudomonas Aeruginosa Enolase Influences Bacterial Tolerance to Oxidative Stresses and Virulence
Frontiers in microbiology. 7 [DOI] 10.3389/fmicb.2016.01999. [PMID] 28018326.
2016
Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis.
Journal of medicinal chemistry. 59(8):3808-25 [DOI] 10.1021/acs.jmedchem.5b02004. [PMID] 27018907.
2016
Structure-Function Analysis of the Transmembrane Protein Ampg From Pseudomonas Aeruginosa
PLoS One. 11(12) [DOI] 10.1371/journal.pone.0168060. [PMID] 27959942.
2016
Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways.
Chemistry (Weinheim an der Bergstrasse, Germany). 22(27):9181-9 [DOI] 10.1002/chem.201600926. [PMID] 27245927.
2016
TatC-dependent translocation of pyoverdine is responsible for the microbial growth suppression.
Journal of microbiology (Seoul, Korea). 54(2):122-30 [DOI] 10.1007/s12275-016-5542-9. [PMID] 26832668.
2015
A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria.
ChemMedChem. 10(7):1157-62 [DOI] 10.1002/cmdc.201500179. [PMID] 25982664.
2015
A practical guide to induced pluripotent stem cell research using patient samples.
Laboratory investigation; a journal of technical methods and pathology. 95(1):4-13 [DOI] 10.1038/labinvest.2014.104. [PMID] 25089770.
2015
Bromophenazine Derivatives With Potent Inhibition, Dispersion and Eradication Activities Against Staphylococcus Aureus Biofilms
Rsc Advances. 5(2):1120-1124 [DOI] 10.1039/c4ra08728c.
2015
Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors.
Scientific reports. 5 [DOI] 10.1038/srep15014. [PMID] 26449528.
2015
Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins.
Stem cells translational medicine. 4(8):913-26 [DOI] 10.5966/sctm.2015-0030. [PMID] 26062981.
2015
Expression and Efficient Purification of Tag-Cleaved Active Recombinant Human Insulin-Like Growth Factor-II From Escherichia Coli
Biotechnology and Bioprocess Engineering. 20(2):234-241 [DOI] 10.1007/s12257-014-0562-y.
2015
Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.
Stem cells (Dayton, Ohio). 33(6):1829-38 [DOI] 10.1002/stem.1970. [PMID] 25702800.
2015
Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis.
Angewandte Chemie (International ed. in English). 54(49):14819-23 [DOI] 10.1002/anie.201508155. [PMID] 26480852.
2015
Optimization of a miniaturized fluid array device for cell-free protein synthesis.
Biotechnology and bioengineering. 112(12):2459-67 [DOI] 10.1002/bit.25668. [PMID] 26037852.
2015
Suhb Is a Novel Ribosome Associated Protein That Regulates Expression of Mexxy By Modulating Ribosome Stalling in Pseudomonas Aeruginosa
Molecular microbiology. 98(2):370-383 [DOI] 10.1111/mmi.13126. [PMID] 26179141.
2014
A Novel Pseudomonas Aeruginosa-Derived Effector Cooperates With Flagella To Mediate the Upregulation of Interleukin 8 in Human Epithelial Cells
Microbial Pathogenesis. 66:24-28 [DOI] 10.1016/j.micpath.2013.12.001. [PMID] 24361345.
2014
Bacterial Delivery of Talen Proteins for Human Genome Editing
PLoS One. 9(3) [DOI] 10.1371/journal.pone.0091547. [PMID] 24618838.
2014
Distinct roles of major peptidoglycan recycling enzymes in β-Lactamase production in Shewanella oneidensis.
Antimicrobial agents and chemotherapy. 58(11):6536-43 [DOI] 10.1128/AAC.03238-14. [PMID] 25136029.
2014
Nucleoside Diphosphate Kinase and Flagellin From Pseudomonas Aeruginosa Induce Interleukin 1 Expression Via the Akt/Nf-Kappa B Signaling Pathways
Infection and Immunity. 82(8):3252-3260 [DOI] 10.1128/IAI.02007-14. [PMID] 24866792.
2014
Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis.
Organic & biomolecular chemistry. 12(6):881-6 [DOI] 10.1039/c3ob42416b. [PMID] 24389824.
2014
Prtr Homeostasis Contributes To Pseudomonas Aeruginosa Pathogenesis and Resistance Against Ciprofloxacin
Infection and Immunity. 82(4):1638-1647 [DOI] 10.1128/IAI.01388-13. [PMID] 24491574.
2014
Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system.
Microbiology (Reading, England). 160(Pt 7):1417-1426 [DOI] 10.1099/mic.0.078139-0. [PMID] 24699069.
2014
Pseudomonas Aeruginosa-Induced Il-1 Beta Production Is Inhibited By Sophora Flavescens Via the Nf-Kappa B/Inflammasome Pathways
Journal of Microbiology. 52(12):1044-1049 [DOI] 10.1007/s12275-014-4512-3. [PMID] 25467122.
2013
Development of a novel ex vivo porcine skin explant model for the assessment of mature bacterial biofilms.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 21(5):704-14 [DOI] 10.1111/wrr.12074. [PMID] 23927831.
2013
Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein.
Cellular reprogramming. 15(2):117-25 [DOI] 10.1089/cell.2012.0058. [PMID] 23438194.
2013
High Level Expression, Efficient Purification and Bioactivity Assay of Recombinant Human Platelet-Derived Growth Factor Aa Dimer (Pdgf-Aa) From Methylotrophic Yeast Pichia Pastoris
Protein Expression and Purification. 91(2):221-227 [DOI] 10.1016/j.pep.2013.08.008. [PMID] 23978536.
2013
Suhb Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas Aeruginosa
Mbio. 4(6):e00419-13 [DOI] 10.1128/mBio.00419-13. [PMID] 24169572.
2013
The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.
Journal of cell science. 126(Pt 16):3638-48 [DOI] 10.1242/jcs.124925. [PMID] 23750005.
2012
B Segregation To Grain Boundaries and Diffusion in Polycrystalline Si With Flash Annealing
Journal of Applied Physics. 111(4) [DOI] 10.1063/1.3688246.
2012
Bioinformatic Analysis of the Acinetobacter Baumannii Phage Ab1 Genome
Gene. 507(2):125-134 [DOI] 10.1016/j.gene.2012.07.029. [PMID] 22868206.
2012
Bms309403 Stimulates Glucose Uptake in Myotubes Through Activation of Amp-Activated Protein Kinase
PLoS One. 7(8) [DOI] 10.1371/journal.pone.0044570. [PMID] 22952994.
2012
Gene Identification in Pseudomonas Aeruginosa: From Bioinformatics To Experimental Analysis
The FASEB's Journal. 26
2012
High Level Expression, Purification and Characterization of Active Fusion Human C1Q and Tumor Necrosis Factor Related Protein 2 (Hctrp2) in Escherichia Coli (Vol 79, Pg 1, 2011)
Protein Expression and Purification. 82(1) [DOI] 10.1016/j.pep.2011.11.005.
2012
The Pseudomonas Aeruginosa Type III Secretion System Has An Exotoxin S/T/Y Independent Pathogenic Role During Acute Lung Infection
PLoS One. 7(7) [DOI] 10.1371/journal.pone.0041547. [PMID] 22844497.
2011
Autoinduction of a Genetic Locus Encoding Putative Acyltransferase in Corynebacterium Glutamicum
Biotechnology Letters. 33(1):97-102 [DOI] 10.1007/s10529-010-0395-5. [PMID] 20821248.
2011
Bacterial delivery of nuclear proteins into pluripotent and differentiated cells.
PloS one. 6(1) [DOI] 10.1371/journal.pone.0016465. [PMID] 21304583.
2011
High Level Expression of Active Recombinant Human Interleukin-3 in Pichia Pastoris
Protein Expression and Purification. 80(2):185-193 [DOI] 10.1016/j.pep.2011.08.027. [PMID] 21907288.
2011
High Level Expression, Purification and Characterization of Active Fusion Human C1Q and Tumor Necrosis Factor Related Protein 2 (Hctrp2) in Escherichia Coli
Protein Expression and Purification. 79(1):1-6 [DOI] 10.1016/j.pep.2011.03.013. [PMID] 21453774.
2011
Interface Stability in Stressed Solid-Phase Epitaxial Growth
Journal of Vacuum Science & Technology B. 29(4) [DOI] 10.1116/1.3610172.
2011
Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris.
FEMS yeast research. 11(2):160-7 [DOI] 10.1111/j.1567-1364.2010.00701.x. [PMID] 21176103.
2011
MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa.
Journal of bacteriology. 193(2):399-410 [DOI] 10.1128/JB.01079-10. [PMID] 21075931.
2011
Mutation of Pfm Affects the Adherence of Pseudomonas Aeruginosa To Host Cells and the Quorum Sensing System
Fems Microbiology Letters. 324(2):173-180 [DOI] 10.1111/j.1574-6968.2011.02401.x. [PMID] 22092819.
2011
N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance.
American journal of respiratory cell and molecular biology. 44(6):824-30 [DOI] 10.1165/rcmb.2009-0285OC. [PMID] 20693405.
2011
Pulsed-Laser Atom Probe Tomography of P-Type Field Effect Transistors On Si-On-Insulator Substrates
Journal of Vacuum Science & Technology B. 29(6) [DOI] 10.1116/1.3647879.
2010
ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.
Antimicrobial agents and chemotherapy. 54(11):4772-9 [DOI] 10.1128/AAC.00009-10. [PMID] 20713660.
2010
Cell-free expression of soluble and membrane proteins in an array device for drug screening.
Analytical chemistry. 82(16):7021-6 [DOI] 10.1021/ac1015479. [PMID] 20666430.
2010
Dopant Measurements in Semiconductors With Atom Probe Tomography
Journal of Vacuum Science & Technology B. 28(1):C1E1-C1E4 [DOI] 10.1116/1.3242422.
2010
Miniaturized fluid array for high-throughput protein expression.
Biotechnology progress. 26(6):1590-6 [DOI] 10.1002/btpr.474. [PMID] 20661923.
2010
Mkp1 Regulates the Induction of Inflammatory Response By Pneumococcal Pneumolysin in Human Epithelial Cells
Fems Immunology and Medical Microbiology. 60(2):171-178 [DOI] 10.1111/j.1574-695X.2010.00733.x. [PMID] 20868379.
2010
Mkp1 Regulates the Induction of Mcp1 By Streptococcus Pneumoniae Pneumolysin in Human Epithelial Cells
Molecules and Cells. 30(3):263-270 [DOI] 10.1007/s10059-010-0113-0. [PMID] 20803086.
2010
Role of Pneumococcal Pneumolysin in the Induction of An Inflammatory Response in Human Epithelial Cells
Fems Immunology and Medical Microbiology. 60(1):28-35 [DOI] 10.1111/j.1574-695X.2010.00699.x. [PMID] 20528932.
2010
Sensitive detection of multiplex toxins using antibody microarray.
Analytical biochemistry. 401(2):271-9 [DOI] 10.1016/j.ab.2010.02.040. [PMID] 20226158.
2010
Sequence Analysis of Pkf3-70 in Klebsiella Pneumoniae: Probable Origin From R100-Like Plasmid of Escherichia Coli
PLoS One. 5(1) [DOI] 10.1371/journal.pone.0008601. [PMID] 20066042.
2009
Expression, Purification, and Functional Characterization of Recombinant Human Interleukin-7
Protein Expression and Purification. 63(1):1-4 [DOI] 10.1016/j.pep.2008.08.009. [PMID] 18805490.
2009
High Level Expression and Purification of Active Recombinant Human Interleukin-8 in Pichia Pastoris
Protein Expression and Purification. 68(1):60-64 [DOI] 10.1016/j.pep.2009.06.010. [PMID] 19545634.
2008
A Systematic Survey of Mini-Proteins in Bacteria and Archaea
PLoS One. 3(12) [DOI] 10.1371/journal.pone.0004027. [PMID] 19107199.
2008
Effect of Carbon Codoping On Boron Diffusion in Amorphous Silicon
Applied Physics Letters. 93(7) [DOI] 10.1063/1.2975833.
2008
Functional Characterization of Miga and Wapr: Putative Rhamnosyltransferases Involved in Outer Core Oligosaccharide Biosynthesis of Pseudomonas Aeruginosa
Journal of bacteriology. 190(6):1857-1865 [DOI] 10.1128/JB.01546-07. [PMID] 18178733.
2008
Mkp1 Regulates the Induction of Muc5Ac Mucin By Streptococcus Pneumoniae Pneumolysin By Inhibiting the Pak4-Jnk Signaling Pathway
Journal of Biological Chemistry. 283(45):30624-30631 [DOI] 10.1074/jbc.M802519200. [PMID] 18782768.
2008
The Pseudomonas Aeruginosa Type Iii Secretion System Plays a Dual Role in the Regulation of Caspase-1 Mediated Il-1 Beta Maturation
Journal of Cellular and Molecular Medicine. 12(5A):1767-1776 [DOI] 10.1111/j.1582-4934.2007.00190.x. [PMID] 18081695.
2007
Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa.
Journal of bacteriology. 189(7):2599-609 [PMID] 17237176.
View on: PubMed
2006
ExoS of Pseudomonas aeruginosa induces apoptosis through a Fas receptor/caspase 8-independent pathway in HeLa cells.
Cellular microbiology. 8(2):326-38 [PMID] 16441442.
View on: PubMed
2006
Expression of Pseudomonas aeruginosa toxin ExoS effectively induces apoptosis in host cells.
Infection and immunity. 74(12):6557-70 [PMID] 16966406.
View on: PubMed
2006
Ricin detection by biological signal amplification in a well-in-a-well device.
Analytical chemistry. 78(22):7659-64 [PMID] 17105156.
View on: PubMed
2005
Factors triggering type III secretion in Pseudomonas aeruginosa.
Microbiology (Reading, England). 151(Pt 11):3575-3587 [DOI] 10.1099/mic.0.28277-0. [PMID] 16272380.
2005
PtrB of Pseudomonas aeruginosa suppresses the type III secretion system under the stress of DNA damage.
Journal of bacteriology. 187(17):6058-68 [PMID] 16109947.
View on: PubMed
2005
Toxin detection by a miniaturized in vitro protein expression array.
Analytical chemistry. 77(17):5494-500 [PMID] 16131058.
View on: PubMed
2004
A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America. 101(42):15027-32 [PMID] 15477593.
View on: PubMed
2004
An in vivo inducible gene of Pseudomonas aeruginosa encodes an anti-ExsA to suppress the type III secretion system.
Molecular microbiology. 54(2):307-20 [PMID] 15469505.
View on: PubMed
2004
Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 2):374-5 [PMID] 14747730.
View on: PubMed
2004
MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa.
Journal of bacteriology. 186(22):7575-85 [PMID] 15516570.
View on: PubMed
2004
Mutants of Agrobacterium tumefaciens virG gene that activate transcription of vir promoter in Escherichia coli.
Current microbiology. 49(5):334-40 [PMID] 15486707.
View on: PubMed
2004
Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.
Journal of structural biology. 146(3):416-24 [PMID] 15099582.
View on: PubMed
2004
Structural insights and functional implications of choline acetyltransferase.
Journal of structural biology. 148(2):226-35 [PMID] 15477102.
View on: PubMed
2004
Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles.
Analytical biochemistry. 334(1):135-44 [PMID] 15464962.
View on: PubMed
2003
aph(3′)-IIb, a gene encoding an aminoglycoside-modifying enzyme, is under the positive control of surrogate regulator HpaA.
Antimicrobial agents and chemotherapy. 47(12):3867-76 [PMID] 14638496.
View on: PubMed
2003
c-Jun NH2-terminal kinase-mediated signaling is essential for Pseudomonas aeruginosa ExoS-induced apoptosis.
Infection and immunity. 71(6):3361-70 [PMID] 12761120.
View on: PubMed
2003
DsbA of Pseudomonas aeruginosa is essential for multiple virulence factors.
Infection and immunity. 71(3):1590-5 [PMID] 12595484.
View on: PubMed
2003
Regulation of membrane permeability by a two-component regulatory system in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy. 47(1):95-101 [PMID] 12499175.
View on: PubMed
2001
Growth phase-dependent invasion of Pseudomonas aeruginosa and its survival within HeLa cells.
Infection and immunity. 69(7):4398-406 [PMID] 11401979.
View on: PubMed
2001
Reconstitution of acetosyringone-mediated Agrobacterium tumefaciens virulence gene expression in the heterologous host Escherichia coli.
Journal of bacteriology. 183(12):3704-11 [PMID] 11371534.
View on: PubMed
2000
migA, a quorum-responsive gene of Pseudomonas aeruginosa, is highly expressed in the cystic fibrosis lung environment and modifies low-molecular-mass lipopolysaccharide.
Microbiology (Reading, England). 146 ( Pt 10):2509-2519 [DOI] 10.1099/00221287-146-10-2509. [PMID] 11021926.

Grants

Sep 2017 – Aug 2018
Optimizing systemic stem/progenitor cell therapy for AMD
Role: Co-Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM via NATL INST OF HLTH NEI
Jul 2016 – Sep 2020
A stem cell tactic to promote personalized medicine
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2015 – Jun 2017
Countering beta-lactam resistance in Pseudomonas aeruginosa
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2014 – May 2016
Development of Potent 2,4-Dibromophenazine Antibacterial Antibiofilm Agents
Role: Project Manager
Funding: UF DSR OPPORTUNITY FUND
Jul 2013 – Aug 2017
Role of CX3CR1 and CCR2 in controlling microglia and mononuclear cells in AMD
Role: Project Manager
Funding: INDIANA UNIV via NATL INST OF HLTH
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Patents

Issued January 2018
Phenazine Derivatives as Antimicrobial Agents
#9,856,225
Published April 2016
Directed Differentiation of Pluripotent Stem Cells By Bacterial Injection of Talen Proteins
#us18/0320153
Issued December 2013
Bacterial Type III Secretion System Mediated Delivery of Reprogramming Factors
#8,617,888
Issued April 2009
Functionalized Nanoparticles and Methods of Use
#7,524,630
Issued September 2007
Two-Component Regulatory Genes Regulating Bacterial Cell Permeability
#7,271,005
Published April 2003
Modulation of Bacterial Membrane Permeability
#US-2003-0232412-A1

Teaching Profile

Courses Taught
2016-2022
GMS6108 Bacterial Physiology, Antibiotics, and Genetics
2020-2022
GMS6132 Introductory Gene and Immunotherapy
2020-2022
GMS6169 Antimicrobial Strategies
2013,2016-2019,2019
GMS6153 Advanced Bacterial Genetics
2019
GMS6506 Biologic Drug Development
2018
CHM7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018
BMS6300 Fund Micro and Immuno
2014-2016
GMS6331 Stem Cell Biology
2016
GMS5905 Special Topics in Biomedical Sciences
2008,2010-2014,2014
GMS6121 Infectious Diseases
2008-2011
GMS6198 Bacterial Pathogenesis Journal Club
2006-2011
GMS7191 Research Conference
2006-2007
GMS7192 Journal Colloquy
2006-2007
GMS6181 Spec Topics Microbiol

Contact Details

Phones:
Business:
(352) 273-5973
Emails:
Business:
sjin@ufl.edu