Ann Progulske-Fox, PhD
Distinguished Professor & Program Director
Teaching Profile
Courses Taught
2011-2024
DEN5127 Infectious Diseases
2018
GMS7980 Research for Doctoral Dissertation
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2013-2016
IDH4905 Individual Work
2011-2012
GMS6161 Introduction to Oral Biology II
2011
DEN8290 Special Topics
2009
ALS4905 Problems in Agricul
2021
GMS6162 Oral Microbiology and Immunology
Publications
Academic Articles
2025
Labelling of a live obligate anaerobe using fluorescent D-amino acids.
Anaerobe.
91
[DOI] 10.1016/j.anaerobe.2025.102939.
[PMID] 39814196.
2022
A randomized controlled trial to evaluate the effectiveness of a novel mouth rinse in patients with gingivitis.
BMC oral health.
22(1)
[DOI] 10.1186/s12903-022-02518-2.
[PMID] 36324127.
2022
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1).
Neoplasia (New York, N.Y.).
31
[DOI] 10.1016/j.neo.2022.100813.
[PMID] 35834946.
2022
VBNC, previously unrecognized in the life cycle of Porphyromonas gingivalis?
Journal of oral microbiology.
14(1)
[DOI] 10.1080/20002297.2021.1952838.
[PMID] 35035782.
2021
A Novel Regulation of K-antigen Capsule Synthesis in Porphyromonas gingivalis Is Driven by the Response Regulator PG0720-Directed Antisense RNA.
Frontiers in oral health.
2
[DOI] 10.3389/froh.2021.701659.
[PMID] 35048039.
2021
Subgingival microbiome of deep and shallow periodontal sitesĀ in patients with rheumatoid arthritis: a pilot study.
BMC oral health.
21(1)
[DOI] 10.1186/s12903-021-01597-x.
[PMID] 33964928.
2020
A Uniquely Altered Oral Microbiome Composition Was Observed in Pregnant Rats With Porphyromonas gingivalis Induced Periodontal Disease.
Frontiers in cellular and infection microbiology.
10
[DOI] 10.3389/fcimb.2020.00092.
[PMID] 32211345.
2020
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Journal of oral microbiology.
13(1)
[DOI] 10.1080/20002297.2020.1849493.
[PMID] 33391626.
2020
Porphyromonas gingivalis W83 traffics via ICAM1 in microvascular endothelial cells and alters capillary organization in vivo.
Journal of oral microbiology.
12(1)
[DOI] 10.1080/20002297.2020.1742528.
[PMID] 32341760.
2019
Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B.
Data in brief.
22:964-970
[DOI] 10.1016/j.dib.2018.12.087.
[PMID] 30740479.
2019
The Importance of Being an Antagonist as Well as Persistent.
Journal of bacteriology.
201(11)
[DOI] 10.1128/JB.00146-19.
[PMID] 30910810.
2019
Tribute: Edward ‘Ned’ Lally.
Molecular oral microbiology.
34(6):235-236
[DOI] 10.1111/omi.12269.
[PMID] 31637856.
2018
Deletion of a conserved transcript PG_RS02100 expressed during logarithmic growth in Porphyromonas gingivalis results in hyperpigmentation and increased tolerance to oxidative stress.
PloS one.
13(11)
[DOI] 10.1371/journal.pone.0207295.
[PMID] 30419070.
2018
Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B.
Journal of periodontology.
89(3):361-369
[DOI] 10.1002/JPER.17-0366.
[PMID] 29543996.
2018
Matrix Metalloproteinase Response of Dendritic Cell, Gingival Epithelial Keratinocyte, and T-Cell Transwell Co-Cultures Treated with Porphyromonas gingivalis Hemagglutinin-B
International Journal of Molecular Sciences.
19(12)
[DOI] 10.3390/ijms19123923.
[PMID] 30544510.
2018
Porphyromonas gingivalis and adverse pregnancy outcome.
Journal of oral microbiology.
10(1)
[DOI] 10.1080/20002297.2017.1374153.
[PMID] 29291034.
2018
Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat.
Biology of reproduction.
99(5):1045-1056
[DOI] 10.1093/biolre/ioy119.
[PMID] 29788108.
2017
Genome Sequence of Porphyromonas gingivalis Strain 381.
Genome announcements.
5(2)
[DOI] 10.1128/genomeA.01467-16.
[PMID] 28082501.
2017
Genome Sequence of Porphyromonas gingivalis Strain A7A1-28.
Genome announcements.
5(10)
[DOI] 10.1128/genomeA.00021-17.
[PMID] 28280013.
2016
Biofilm Formation by Mycobacterium abscessus in a Lung Cavity.
American journal of respiratory and critical care medicine.
193(6):692-3
[DOI] 10.1164/rccm.201508-1586IM.
[PMID] 26731090.
2016
Introduction to the Mark Wilson Conference Special Issue.
Molecular oral microbiology.
31(1):1-2
[DOI] 10.1111/omi.12148.
[PMID] 26754252.
2016
Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome.
PloS one.
11(1)
[DOI] 10.1371/journal.pone.0146157.
[PMID] 26731111.
2015
Genome Sequence of Porphyromonas gingivalis Strain A7436.
Genome announcements.
3(5)
[DOI] 10.1128/genomeA.00927-15.
[PMID] 26404590.
2015
Genome Sequence of Porphyromonas gingivalis Strain AJW4.
Genome announcements.
3(6)
[DOI] 10.1128/genomeA.01304-15.
[PMID] 26543127.
2015
Invasion of Porphyromonas gingivalis strains into vascular cells and tissue.
Journal of oral microbiology.
7
[DOI] 10.3402/jom.v7.28788.
[PMID] 26329158.
2015
The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.
Infection and immunity.
83(5):2001-10
[DOI] 10.1128/IAI.03022-14.
[PMID] 25733523.
2014
Expression of Porphyromonas gingivalis small RNA in response to hemin availability identified using microarray and RNA-seq analysis.
FEMS microbiology letters.
351(2):202-8
[DOI] 10.1111/1574-6968.12320.
[PMID] 24245974.
2014
Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.
Scientific reports.
4
[DOI] 10.1038/srep03904.
[PMID] 24473528.
2013
Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.
Scientific reports.
3
[DOI] 10.1038/srep01232.
[PMID] 23390582.
2013
Deletion of lipoprotein PG0717 in Porphyromonas gingivalis W83 reduces gingipain activity and alters trafficking in and response by host cells.
PloS one.
8(9)
[DOI] 10.1371/journal.pone.0074230.
[PMID] 24069284.
2013
Development of a novel ex vivo porcine skin explant model for the assessment of mature bacterial biofilms.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
21(5):704-14
[DOI] 10.1111/wrr.12074.
[PMID] 23927831.
2013
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology.
Journal of periodontology.
84(4 Suppl):S30-50
[DOI] 10.1902/jop.2013.1340012.
[PMID] 23631583.
2013
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology.
Journal of clinical periodontology.
40 Suppl 14:S30-50
[DOI] 10.1111/jcpe.12079.
[PMID] 23627333.
2013
Transforming women’s oral-systemic health through discovery, development, and delivery.
Journal of women's health (2002).
22(4):299-302
[DOI] 10.1089/jwh.2012.4197.
[PMID] 23540329.
2012
Both the unique and repeat regions of the Porphyromonas gingivalis hemagglutin A are involved in adhesion and invasion of host cells.
Anaerobe.
18(1):128-34
[DOI] 10.1016/j.anaerobe.2011.10.005.
[PMID] 22100486.
2012
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy.
8(4):445-544
[PMID] 22966490.
2012
Human Ī²-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells.
International journal of antimicrobial agents.
40(1):75-9
[DOI] 10.1016/j.ijantimicag.2012.03.007.
[PMID] 22578747.
2012
Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice.
Journal of dental research.
91(3):255-60
[DOI] 10.1177/0022034511435101.
[PMID] 22262633.
2012
Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0052606.
[PMID] 23300720.
2010
Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice.
Future microbiology.
5(1):115-25
[DOI] 10.2217/fmb.09.107.
[PMID] 20020833.
2010
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.
PloS one.
5(7)
[DOI] 10.1371/journal.pone.0011714.
[PMID] 20668524.
2009
A member of the peptidase M48 superfamily of Porphyromonas gingivalis is associated with virulence in vitro and in vivo.
Journal of oral microbiology.
1
[DOI] 10.3402/jom.v1i0.2021.
[PMID] 21523206.
2009
Analysis of a band 7/MEC-2 family gene of Porphyromonas gingivalis.
Journal of dental research.
88(1):34-8
[DOI] 10.1177/0022034508328381.
[PMID] 19131314.
2009
Identification of Compounds That Enhance and Suppress Autophagy
Autophagy.
5:910-911
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology.
24(2):141-5
[DOI] 10.1111/j.1399-302X.2008.00487.x.
[PMID] 19239641.
2008
Colonization of maternal and fetal tissues by Porphyromonas gingivalis is strain-dependent in a rodent animal model.
American journal of obstetrics and gynecology.
199(1):86.e1-7
[DOI] 10.1016/j.ajog.2007.11.067.
[PMID] 18355778.
2008
Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalis.
Infection and immunity.
76(12):5714-20
[DOI] 10.1128/IAI.00997-08.
[PMID] 18852241.
2008
Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.
Immunology and cell biology.
86(8):643-9
[DOI] 10.1038/icb.2008.56.
[PMID] 18711400.
2008
Invasive differences among Porphyromonas gingivalis strains from healthy and diseased periodontal sites.
Journal of periodontal research.
43(5):524-30
[DOI] 10.1111/j.1600-0765.2007.01064.x.
[PMID] 18544120.
2008
Porphyromonas gingivalis and the autophagic pathway: an innate immune interaction?
Frontiers in bioscience : a journal and virtual library.
13:178-87
[PMID] 17981536.
2008
Porphyromonas gingivalis htrA is involved in cellular invasion and in vivo survival.
Microbiology (Reading, England).
154(Pt 4):1161-1169
[DOI] 10.1099/mic.0.2007/015131-0.
[PMID] 18375808.
2007
Conjugal transfer of chromosomal DNA contributes to genetic variation in the oral pathogen Porphyromonas gingivalis.
Journal of bacteriology.
189(17):6382-8
[PMID] 17573478.
2007
Genetic manipulation of Porphyromonas gingivalis.
Current protocols in microbiology.
Chapter 13
[DOI] 10.1002/9780471729259.mc13c02s05.
[PMID] 18770611.
2007
Identification of Tannerella forsythia antigens specifically expressed in patients with periodontal disease.
FEMS microbiology letters.
275(2):344-52
[PMID] 17868359.
2007
In vitro activity of amoxicillin, clindamycin, doxycycline, metronidazole, and moxifloxacin against oral Actinomyces.
Journal of endodontics.
33(5):557-60
[PMID] 17437871.
2007
The Porphyromonas gingivalis clpB gene is involved in cellular invasion in vitro and virulence in vivo.
FEMS immunology and medical microbiology.
51(2):388-98
[PMID] 17854400.
2006
Antimicrobial efficacy of medicated root canal filling materials.
Journal of endodontics.
32(2):148-51
[PMID] 16427466.
2006
Autophagy: a highway for Porphyromonas gingivalis in endothelial cells.
Autophagy.
2(3):165-70
[PMID] 16874051.
2006
Detection of bacterial DNA in atheromatous plaques by quantitative PCR.
Microbes and infection.
8(3):687-93
[PMID] 16513386.
2005
Dentinal tubule disinfection using three calcium hydroxide formulations.
Journal of endodontics.
31(1):50-2
[PMID] 15614007.
2005
Distinct transcriptional profiles characterize oral epithelium-microbiota interactions.
Cellular microbiology.
7(6):811-23
[PMID] 15888084.
2005
Gene expression profile analysis of Porphyromonas gingivalis during invasion of human coronary artery endothelial cells.
Infection and immunity.
73(9):6169-73
[PMID] 16113342.
2005
Hemagglutinin B is involved in the adherence of Porphyromonas gingivalis to human coronary artery endothelial cells.
Infection and immunity.
73(11):7267-73
[PMID] 16239522.
2005
Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.
Arteriosclerosis, thrombosis, and vascular biology.
25(3):e17-8
[PMID] 15662025.
2005
In vivo induced genes in human diseases.
Periodontology 2000.
38:123-34
[PMID] 15853939.
2005
Microarray analysis of quorum-sensing-regulated genes in Porphyromonas gingivalis.
Infection and immunity.
73(7):4146-54
[PMID] 15972504.
2005
Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection.
Infection and immunity.
73(5):2665-79
[PMID] 15845468.
2004
In vivo induced antigenic determinants of Actinobacillus actinomycetemcomitans.
FEMS microbiology letters.
237(1):97-103
[PMID] 15268943.
2003
Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients.
Infection and immunity.
71(10):5461-71
[PMID] 14500463.
2003
Identification of Candida albicans genes induced during thrush offers insight into pathogenesis.
Molecular microbiology.
48(5):1275-88
[PMID] 12787355.
2003
Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America.
100(14):8508-13
[PMID] 12826608.
2002
Bacterial interactions with the autophagic pathway.
Cellular microbiology.
4(1):1-10
[PMID] 11856168.
2002
Genes of periodontopathogens expressed during human disease.
Annals of periodontology.
7(1):38-42
[PMID] 16013215.
2002
Identification and testing of Porphyromonas gingivalis virulence genes with a pPGIVET system.
Infection and immunity.
70(2):928-37
[PMID] 11796628.
2002
Invasion of vascular cells in vitro by Porphyromonas endodontalis.
International endodontic journal.
35(4):366-71
[PMID] 12059938.
2001
Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease.
Microbial pathogenesis.
30(4):179-92
[PMID] 11312612.
2001
Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells.
Infection and immunity.
69(9):5698-708
[PMID] 11500446.
2001
The effect of monoclonal antibody and route of immunization on the humoral immune response against Porphyromonas gingivalis.
Oral microbiology and immunology.
16(3):153-62
[PMID] 11358537.
2000
Expression and immunogenicity of hemagglutinin A from Porphyromonas gingivalis in an avirulent Salmonella enterica serovar typhimurium vaccine strain.
Infection and immunity.
68(2):732-9
[PMID] 10639440.
2000
Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis.
FEMS microbiology letters.
187(2):139-44
[PMID] 10856647.
2000
IVIAT: a novel method to identify microbial genes expressed specifically during human infections.
Trends in microbiology.
8(7):336-9
[PMID] 10878769.
2000
Long-term immunological memory induced by recombinant oral Salmonella vaccine vectors.
Infection and immunity.
68(7):4370-3
[PMID] 10858264.
1999
Invasion of human coronary artery cells by periodontal pathogens.
Infection and immunity.
67(11):5792-8
[PMID] 10531230.
1999
Porphyromonas gingivalis virulence factors and invasion of cells of the cardiovascular system.
Journal of periodontal research.
34(7):393-9
[PMID] 10685367.
1998
Invasion of human oral epithelial cells by Prevotella intermedia.
Infection and immunity.
66(12):6054-7
[PMID] 9826397.
1998
The number of direct repeats in hagA is variable among Porphyromonas gingivalis strains.
Infection and immunity.
66(10):4721-5
[PMID] 9746569.
1998
The porphyromonas gingivalis prtP/kgp homologue exists as two open reading frames in strain 381.
Oral diseases.
4(3):170-9
[PMID] 9972167.
1996
Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis.
Journal of bacteriology.
178(10):2734-41
[PMID] 8631659.
1996
Construction and preliminary characterization of three hemagglutinin mutants of Porphyromonas gingivalis.
Infection and immunity.
64(4):1467-72
[PMID] 8606121.
1996
Duplication and differential expression of hemagglutinin genes in Porphyromonas gingivalis.
Oral microbiology and immunology.
11(2):65-78
[PMID] 8941757.
1996
The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats.
Infection and immunity.
64(10):4000-7
[PMID] 8926061.
1996
The hemagglutinin genes hagB and hagC of Porphyromonas gingivalis are transcribed in vivo as shown by use of a new expression vector.
Infection and immunity.
64(11):4802-10
[PMID] 8890242.
1995
Expression and immunogenicity of a cloned Porphyromonas gingivalis hemagglutinin in Salmonella typhimurium.
Advances in experimental medicine and biology.
371B:1119-21
[PMID] 7502765.
1995
Restriction fragment length polymorphism analysis of two hemagglutinin loci, serotyping and agglutinating activity of Porphyromonas gingivalis isolates.
Oral microbiology and immunology.
10(1):1-7
[PMID] 7644268.
1995
The cloning, expression and sequence analysis of a second Porphyromonas gingivalis gene that codes for a protein involved in hemagglutination.
Oral microbiology and immunology.
10(5):311-8
[PMID] 8596675.
1994
Systemic and mucosal immune responses in mice orally immunized with avirulent Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin.
Infection and immunity.
62(5):1652-7
[PMID] 8168925.
1993
Cloning and sequencing of two type 4 (N-methylphenylalanine) pilin genes from Eikenella corrodens.
Journal of general microbiology.
139(3):651-60
[PMID] 8473871.
1993
Development of a genetic system for Eikenella corrodens: transfer of plasmids pFM739 and pLES2.
Plasmid.
30(3):289-95
[PMID] 8302938.
1993
Isolation and characterization of a cloned Porphyromonas gingivalis hemagglutinin from an avirulent strain of Salmonella typhimurium.
Infection and immunity.
61(3):940-6
[PMID] 8381773.
1993
Molecular characterization of hemagglutinin genes of periodontopathic bacteria.
Journal of periodontal research.
28(6 Pt 2):473-4
[PMID] 8263716.
1993
Sequence divergence in two tandemly located pilin genes of Eikenella corrodens.
Infection and immunity.
61(5):1909-16
[PMID] 8478080.
1993
Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.
Antimicrobial agents and chemotherapy.
37(9):2037-41
[PMID] 7916585.
1992
Evidence for independent molecular identity and functional interaction of the haemagglutinin and cysteine proteinase (gingivain) of Porphyromonas gingivalis.
Journal of medical microbiology.
36(4):239-44
[PMID] 1313881.
1991
Identification and sequence analysis of a methylase gene in Porphyromonas gingivalis.
Nucleic acids research.
19(15):4189-92
[PMID] 1870972.
1990
Cloning and inactivation of the gene responsible for a major surface antigen on Streptococcus mutans.
Archives of oral biology.
35 Suppl:15S-23S
[PMID] 2088219.
1989
Construction and characterization of isogenic mutants of Streptococcus mutans deficient in major surface protein antigen P1 (I/II).
Infection and immunity.
57(11):3306-13
[PMID] 2807526.
1989
Sequence analysis of the cloned streptococcal cell surface antigen I/II.
FEBS letters.
258(1):127-32
[PMID] 2687020.
1989
The expression and function of a Bacteroides gingivalis hemagglutinin gene in Escherichia coli.
Oral microbiology and immunology.
4(3):121-31
[PMID] 2700777.
1989
Transfer of plasmid pE5-2 from Escherichia coli to Bacteroides gingivalis and B. intermedius.
Oral microbiology and immunology.
4(3):132-4
[PMID] 2700778.
1988
Molecular cloning and expression of a Streptococcus mutans major surface protein antigen, P1 (I/II), in Escherichia coli.
Infection and immunity.
56(8):2114-9
[PMID] 3135272.
1987
The effect of Eikenella corrodens endotoxin on periapical bone.
Journal of endodontics.
13(12):559-65
[PMID] 3329211.
1975
The 6-hydroxydopamine rotational model for the detection of dopamine agonist activity: reliability of effect from different locations of 6-hydroxydopamine.
The Journal of pharmacy and pharmacology.
27(12):943-6
[PMID] 2668.
Grants
Jan 2021
– Dec 2022
Oral Immunology/Microbiology research group annual meeting
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2019
ACTIVE
Investigating the viable but not culturable (VBNC) state in P. gingivalis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2019
– Dec 2020
Analysis of Mab61BG1.3 reactivity with strains of P. gingivalis.
Role: Principal Investigator
Funding: KEYSTONE BIO
Aug 2019
– Aug 2020
Analysis of antigen reactivity
Role: Principal Investigator
Funding: SALVDX
Jun 2017
– Dec 2018
Clinical effectiveness of Next Science oral rinse in controlling plaque and gingival inflammation
Role: Principal Investigator
Funding: NEXT SCIENCE LLC
Dec 2015
– Feb 2019
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Apr 2015
– Mar 2021
P. gingivalis mediated disruption of autophagy in endothelial dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2014
– Jul 2017
Porphyromonas gingivalis strain specific effects on the deep placental bed
Role: Project Manager
Funding: NATL INST OF HLTH NICHD
Jul 2013
– Dec 2016
Internalization of S. mutans in vascular endothelial cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2011
– May 2017
Periodontal Pathogens and Cardiovascular Disease
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Contact Details
Phones:
- Business:
- (352) 273-8835
Emails:
- Business:
- apfox@dental.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100424
GAINESVILLE FL 32610 - Business Street:
-
DG-50 DSB
GAINESVILLE FL 32611