Frederick S Southwick

Frederick S Southwick, M.D.

PROF

Department: MD-HOSPITAL MEDICINE DIVISION
Business Phone: (352) 246-8465
Business Email: southf@epi.ufl.edu

Accomplishments

Advanced Leadership Initiative Fellow
2010 · Harvard Business School
Award for distinguished research accomplishments
2001 · University of Florida Research Foundation
Elected Outstanding
2001 · Department of Medicine House Staff
Teaching Excellence Award
2001 · University of Florida
Elected Member
2000 · Association of Professors of Medicine

Board Certifications

  • Infectious Diseases
    American Board of Internal Medicine
  • Internal Medicine
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Medicine
Subspecialties
  • Hospital Medicine
  • Infectious Disease
Areas of Interest
  • Anthrax
  • Atypical pneumonia
  • Community-acquired pneumonia in adults
  • Hospital-acquired pneumonia
  • Immunodeficiency disorders
  • Infectious diseases
  • Meningitis
  • Sepsis
  • Urinary tract infection – adults

Publications

2021
Improving the Definition of Coronavirus Disease 2019-Related Deaths.
The Journal of infectious diseases. 224(3):375-376 [DOI] 10.1093/infdis/jiab271. [PMID] 34000024.
2021
In response: neuraxial and peripheral misconnection events leading to wrong-route medication errors.
Regional anesthesia and pain medicine. 46(12):1117-1118 [DOI] 10.1136/rapm-2021-102672. [PMID] 33858913.
2021
Increasing adherence to a standardized rounding procedure in two hospital in-patient units.
Journal of applied behavior analysis. 54(4):1514-1525 [DOI] 10.1002/jaba.865. [PMID] 34289103.
2021
Neuraxial and peripheral misconnection events leading to wrong-route medication errors: a comprehensive literature review.
Regional anesthesia and pain medicine. 46(2):176-181 [DOI] 10.1136/rapm-2020-101836. [PMID] 33144409.
2020
Health Care Provider Factors Associated with Patient-Reported Adverse Events and Harm.
Joint Commission journal on quality and patient safety. 46(5):282-290 [DOI] 10.1016/j.jcjq.2020.02.004. [PMID] 32362355.
2020
Infectious diseases occurring in the context of substance use disorders: A concise review.
Journal of the Neurological Sciences. 411 [DOI] 10.1016/j.jns.2020.116719. [PMID] 32070807.
2020
No human exists in isolation or as an island: The outcomes of a multidisciplinary, global, and context-specific COVID-19 consortium.
American journal of disaster medicine. 15(3):219-222 [DOI] 10.5055/ajdm.2020.0350. [PMID] 33270212.
2020
The Loss of Social Connectedness as a Major Contributor to Physician Burnout: Applying Organizational and Teamwork Principles for Prevention and Recovery.
JAMA psychiatry. 77(5):449-450 [DOI] 10.1001/jamapsychiatry.2019.4800. [PMID] 32074385.
2019
Teaching novice clinicians how to reduce diagnostic waste and errors by applying the Toyota Production System.
Diagnosis (Berlin, Germany). 6(2):179-185 [DOI] 10.1515/dx-2018-0081. [PMID] 30875320.
2018
Learning From Patients’ Experiences Related To Diagnostic Errors Is Essential For Progress In Patient Safety.
Health affairs (Project Hope). 37(11):1821-1827 [DOI] 10.1377/hlthaff.2018.0698. [PMID] 30395513.
2018
The Loss of a Sense of Control as a Major Contributor to Physician Burnout: A Neuropsychiatric Pathway to Prevention and Recovery.
JAMA psychiatry. 75(7):665-666 [DOI] 10.1001/jamapsychiatry.2018.0566. [PMID] 29799941.
2016
The lazy leukocyte syndrome revisited.
Blood. 128(17):2112-2113 [PMID] 27789436.
View on: PubMed
2015
A patient-initiated voluntary online survey of adverse medical events: the perspective of 696 injured patients and families.
BMJ quality & safety. 24(10):620-9 [DOI] 10.1136/bmjqs-2015-003980. [PMID] 26092166.
2014
Applying athletic principles to medical rounds to improve teaching and patient care.
Academic medicine : journal of the Association of American Medical Colleges. 89(7):1018-23 [DOI] 10.1097/ACM.0000000000000278. [PMID] 24979169.
2014
Exserohilum rostratum: characterization of a cross-kingdom pathogen of plants and humans.
PloS one. 9(10) [DOI] 10.1371/journal.pone.0108691. [PMID] 25285444.
2013
Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
Cellular microbiology. 15(3):353-367 [DOI] 10.1111/cmi.12051. [PMID] 23083060.
2012
All’S Not Fair in Science and Publishing
Scientist. 26:24-25
2012
Anthrax lethal and edema toxins fail to directly impair human platelet function.
The Journal of infectious diseases. 205(3):453-7 [DOI] 10.1093/infdis/jir763. [PMID] 22158563.
2012
Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes.
BMC immunology. 13 [DOI] 10.1186/1471-2172-13-33. [PMID] 22747600.
2012
Perspective: a business school view of medical interprofessional rounds: transforming rounding groups into rounding teams.
Academic medicine : journal of the Association of American Medical Colleges. 87(12):1768-71 [DOI] 10.1097/ACM.0b013e318271f8da. [PMID] 23095926.
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0018890. [PMID] 21573031.
2010
Brucella, voles, and emerging pathogens.
The Journal of infectious diseases. 202(1):1-2 [DOI] 10.1086/653085. [PMID] 20497041.
2010
Commentary: IDSA guidelines for improving the teaching of preclinical medical microbiology and infectious diseases.
Academic medicine : journal of the Association of American Medical Colleges. 85(1):19-22 [DOI] 10.1097/ACM.0b013e3181c485c5. [PMID] 20042815.
2009
Bacillus anthracis edema toxin impairs neutrophil actin-based motility.
Infection and immunity. 77(6):2455-64 [DOI] 10.1128/IAI.00839-08. [PMID] 19349425.
2009
Commentary: “Who was caring for Mary?” revisited: a call for all academic physicians caring for patients to focus on systems and quality improvement.
Academic medicine : journal of the Association of American Medical Colleges. 84(12):1648-50 [DOI] 10.1097/ACM.0b013e3181bf9f80. [PMID] 19940566.
2008
Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field.
Infection control and hospital epidemiology. 29(5):450-3 [DOI] 10.1086/587971. [PMID] 18419370.
2007
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.
The EMBO journal. 26(9):2240-50 [PMID] 17446863.
View on: PubMed
2007
Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook.
Transactions of the American Clinical and Climatological Association. 118:115-22 [PMID] 18528495.
View on: PubMed
2006
A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
The EMBO journal. 25(19):4458-67 [PMID] 16977317.
View on: PubMed
2005
Anthrax lethal toxin paralyzes neutrophil actin-based motility.
The Journal of infectious diseases. 192(5):837-45 [PMID] 16088833.
View on: PubMed
2005
Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.
Proceedings of the National Academy of Sciences of the United States of America. 102(6):1921-6 [PMID] 15671163.
View on: PubMed
2005
Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation.
The Journal of biological chemistry. 280(12):11379-86 [PMID] 15642729.
View on: PubMed
2003
Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
Cell motility and the cytoskeleton. 54(1):41-55 [PMID] 12451594.
View on: PubMed
2003
CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity. 71(11):6582-90 [PMID] 14573680.
View on: PubMed
2003
Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
The Journal of biological chemistry. 278(27):24629-35 [PMID] 12730212.
View on: PubMed
2002
A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
Archives of biochemistry and biophysics. 406(2):296-301 [PMID] 12361718.
View on: PubMed
2002
Actin-based phagosome motility.
Cell motility and the cytoskeleton. 53(2):81-8 [PMID] 12211106.
View on: PubMed
2002
Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America. 99(26):16782-7 [PMID] 12464680.
View on: PubMed
2002
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Molecular medicine (Cambridge, Mass.). 8(1):56-64 [PMID] 11984006.
View on: PubMed
2001
Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.
The Journal of cell biology. 154(4):775-84 [PMID] 11514591.
View on: PubMed
2001
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Nature cell biology. 3(10):897-904 [PMID] 11584271.
View on: PubMed
2001
Who was caring for Mary? 1993.
Obstetrics and gynecology. 98(6):1140-2 [PMID] 11755567.
View on: PubMed
2000
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
Proceedings of the National Academy of Sciences of the United States of America. 97(13):6936-8 [PMID] 10860951.
View on: PubMed
2000
Shigella actin-based motility in the presence of truncated vinculin.
Cell motility and the cytoskeleton. 45(4):272-8 [PMID] 10744860.
View on: PubMed
1999
Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular cell biology research communications : MCBRC. 1(3):176-81 [PMID] 10425223.
View on: PubMed
1999
Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular Cell Biology Research Communications. 1(3) [DOI] 10.1006/mcbr.1999.0128. [PMID] 10425223.
1999
Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
Methods in enzymology. 308:93-111 [PMID] 10507002.
View on: PubMed
1999
Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
The Journal of biological chemistry. 274(52):36963-72 [PMID] 10601251.
View on: PubMed
1998
Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells.
Infection and immunity. 66(8):3775-82 [PMID] 9673261.
View on: PubMed
1998
Listeria and Shigella actin-based motility in host cells.
Transactions of the American Clinical and Climatological Association. 109:160-72; discussion 172 [PMID] 9601135.
View on: PubMed
1998
Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.
Proceedings of the National Academy of Sciences of the United States of America. 95(23):13917-22 [PMID] 9811901.
View on: PubMed
1997
ABM-1 and ABM-2 homology sequences: consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP.
Biochemical and biophysical research communications. 231(3):686-91 [PMID] 9070872.
View on: PubMed
1997
Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility.
Biochemistry. 36(27):8384-92 [PMID] 9204886.
View on: PubMed
1997
Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.
The Journal of cell biology. 138(6):1255-64 [PMID] 9298981.
View on: PubMed
1996
Intracellular pathogenesis of listeriosis.
The New England journal of medicine. 334(12):770-6 [PMID] 8592552.
View on: PubMed
1996
Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.
Biochemistry. 35(11):3518-24 [PMID] 8639502.
View on: PubMed
1996
Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.
The Journal of cell biology. 133(1):49-59 [PMID] 8601612.
View on: PubMed
1995
Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
The Journal of biological chemistry. 270(1):45-8 [PMID] 7814409.
View on: PubMed
1995
Inhibition of Listeria locomotion by mosquito oostatic factor, a natural oligoproline peptide uncoupler of profilin action.
Infection and immunity. 63(1):182-90 [PMID] 7806356.
View on: PubMed
1995
Listeria monocytogenes intracellular migration: inhibition by profilin, vitamin D-binding protein and DNase I.
Cell motility and the cytoskeleton. 30(1):38-49 [PMID] 7728867.
View on: PubMed
1995
Septic thrombophlebitis of major dural venous sinuses.
Current clinical topics in infectious diseases. 15:179-203 [PMID] 7546367.
View on: PubMed
1994
Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
Proceedings of the National Academy of Sciences of the United States of America. 91(11):5168-72 [PMID] 8197202.
View on: PubMed
1994
Calcium regulation of actin filament capping and monomer binding by macrophage capping protein.
The Journal of biological chemistry. 269(19):13997-4002 [PMID] 8188679.
View on: PubMed
1994
Dynamic remodeling of the actin cytoskeleton: lessons learned from Listeria locomotion.
BioEssays : news and reviews in molecular, cellular and developmental biology. 16(12):885-91 [PMID] 7840767.
View on: PubMed
1994
The human actin-regulatory protein cap G: gene structure and chromosome location.
Genomics. 23(3):560-5 [PMID] 7851883.
View on: PubMed
1993
Acute bacterial meningitis in adults. A review of 493 episodes.
The New England journal of medicine. 328(1):21-8 [PMID] 8416268.
View on: PubMed
1993
Diminished actin polymerization by neutrophils from newborn infants.
Pediatric research. 33(1):27-31 [PMID] 8433856.
View on: PubMed
1993
Who was caring for Mary?
Annals of internal medicine. 118(2):146-8 [PMID] 8123053.
View on: PubMed
1992
Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
Infection and immunity. 60(9):3609-19 [PMID] 1500169.
View on: PubMed
1992
Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
The Journal of biological chemistry. 267(23):16545-52 [PMID] 1322908.
View on: PubMed
1991
Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway.
Journal of immunology (Baltimore, Md. : 1950). 146(12):4282-8 [PMID] 1828264.
View on: PubMed
1991
Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4-phosphate kinase by concanavalin A and formyl-methionyl-leucyl-phenylalanine is calcium-independent. Correlation with maintenance of actin assembly.
Journal of immunology (Baltimore, Md. : 1950). 147(7):2270-5 [PMID] 1655888.
View on: PubMed
1990
Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period.
Biochemistry. 29(9):2232-40 [PMID] 2337601.
View on: PubMed
1990
Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
Proceedings of the National Academy of Sciences of the United States of America. 87(16):6068-72 [PMID] 2117270.
View on: PubMed
1990
Septic cortical thrombophlebitis.
The Journal of infectious diseases. 161(6):1216-20 [PMID] 2189005.
View on: PubMed
1990
The actin released from profilin–actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.
The Journal of cell biology. 110(6):1965-73 [PMID] 2351690.
View on: PubMed
1989
Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
The Journal of cell biology. 109(4 Pt 1):1561-9 [PMID] 2507552.
View on: PubMed
1989
The relationship between CR3 deficiency and neutrophil actin assembly.
Blood. 73(7):1973-9 [PMID] 2523744.
View on: PubMed
1988
Contractile proteins in leukocytes.
Methods in enzymology. 162:246-71 [PMID] 3226309.
View on: PubMed
1988
Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members.
The Journal of clinical investigation. 82(5):1525-31 [PMID] 3183050.
View on: PubMed
1988
Recurrent cystitis and bladder mass in two adults with chronic granulomatous disease.
Annals of internal medicine. 109(2):118-21 [PMID] 3289429.
View on: PubMed
1987
Platelet-activating factor both stimulates and “primes” human polymorphonuclear leukocyte actin filament assembly.
Blood. 70(6):1921-7 [PMID] 3118991.
View on: PubMed
1986
Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the “barbed” ends of actin filaments but does not sever them.
The Journal of biological chemistry. 261(30):14191-5 [PMID] 3021731.
View on: PubMed
1986
Septic thrombosis of the dural venous sinuses.
Medicine. 65(2):82-106 [PMID] 3512953.
View on: PubMed
1985
Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin.
The Journal of biological chemistry. 260(12):7402-9 [PMID] 2987255.
View on: PubMed
1985
Nonmuscle actin-binding proteins.
Annual review of cell biology. 1:353-402 [PMID] 3030380.
View on: PubMed
1984
An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells.
The Journal of cell biology. 99(3):886-93 [PMID] 6206079.
View on: PubMed
1984
Sphenoid sinusitis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 38(4):214-6 [PMID] 6498309.
View on: PubMed
1984
The motor of leukocytes.
Federation proceedings. 43(12):2760-3 [PMID] 6540718.
View on: PubMed
1983
Contractile proteins in leukocyte function.
Seminars in hematology. 20(4):305-21 [PMID] 6316556.
View on: PubMed
1983
Sphenoid sinusitis. A review of 30 cases.
The New England journal of medicine. 309(19):1149-54 [PMID] 6621661.
View on: PubMed
1982
Acumentin, a protein in macrophages which caps the “pointed” end of action filaments.
Nature. 297(5864):303-7 [PMID] 6281657.
View on: PubMed
1982
Acumentin, an actin-modulating protein of rabbit pulmonary macrophages.
Biochemistry. 21(24):6321-6 [PMID] 7150562.
View on: PubMed
1981
A variant of chronic granulomatous disease: deficient oxidative metabolism due to a low-affinity NADPH oxidase.
The New England journal of medicine. 305(22):1329-33 [PMID] 6270561.
View on: PubMed
1981
Isolation of an inhibitor of actin polymerization from human polymorphonuclear leukocytes.
The Journal of biological chemistry. 256(6):3030-6 [PMID] 6894143.
View on: PubMed
1980
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
The New England journal of medicine. 302(21):1163-8 [PMID] 7366657.
View on: PubMed
1980
Hemophilus influenzae in hospitalized adults: current perspectives.
The American journal of medicine. 69(2):219-26 [PMID] 6967696.
View on: PubMed
1979
Defective leukocyte metabolism.
The New England journal of medicine. 301(8) [PMID] 460358.
View on: PubMed
1977
Multifactorial index of cardiac risk in noncardiac surgical procedures.
The New England journal of medicine. 297(16):845-50 [PMID] 904659.
View on: PubMed

Education

Fellowship – Infectious Disease
1980 · Massachusetts General Hospital
Residency – Internal Medicine
1976 · Massachusetts General Hospital
Residency – Internal Medicine
1975 · Boston City Hospital
Internship – Internal Medicine
1974 · Boston City Hospital
Medical Degree
1973 · Columbia University

Teaching Profile

Courses Taught
2013-2018
MDT7200 Elect Top/Medicine
2016,2018
MDC7200 Medicine Clerkship
2018
MDC7203 Senior Medicine Clerk
2018
BMS6300 Fund Micro and Immuno
2010-2013
MEL7948 Elect Top/Medicine
2021
PAS5020 Intro to Medicine 2

Contact Details

Phones:
Business:
(352) 246-8465
Emails:
Business:
southf@epi.ufl.edu